Table 2.
ABC criteria for the diagnosis of Alzheimer's disease-related pathology. Modified from [17].
| Level of AD neuropathologic change | ||||||
|---|---|---|---|---|---|---|
| Thal phase for Aβ plaques |
A | B | C | CERAD | ||
| 0 or 1 | 2 | 3 | ||||
| 0 | 0 | Not | Not | Not | 0 | neg |
| 1 or 2 | 1 | Low | Low | Low | 0 or 1 | neg or A |
| 1 or 2 | 1 | Low | Intermediate | Intermediate | 2 or 3 | B or C |
| 3 | 2 | Low | Intermediate | Intermediate | any C | neg or A to C |
| 4 or 5 | 3 | Low | Intermediate | Intermediate | 0 or 1 | neg or A |
| 4 or 5 | 3 | Low | Intermediate | High | 2 or 3 | B or C |
| Braak 0-II | Braak III-IV | Braak V-VI | ||||
The level of AD neuropathic change is determined by assessing A, B and C scores. A scores are related to phases of Aβ deposition (first column), B scores to neurofibrillary Braak stages (bottom row) and C scores to CERAD stages (last column). Superimposed on the AD classification are criteria for "definite PART" (yellow) and "possible PART" (blue) based on the same information.