Table 3.
No AD/no PART | Asymptomatic PART | p-preAD | NFT-predominant dementia (symptomatic PART) | Symptomatic AD | |
---|---|---|---|---|---|
Aβ phase | 0 | 0–2 | 1–5 | 0–2 | 3–5 |
Braak-NFT-stage | 0 | I–IV | 0–VI | III, IV | III–VI |
Degree of AD pathology | No AD | No or low AD | Low–high AD | No AD or low | Intermediate–high AD |
Clinical signs of dementia or cognitive decline | No | No | No | Yes | Yes |
PART vs. AD: symptomatic PART and symptomatic AD can be distinguished by Aβ pathology. Asymptomatic PART and p-pre-AD overlap in those cases with initial Aβ pathology (Aβ phases 1, 2)