Table 1.
Baseline patient characteristics (n=480)
| n | % | Median | IQR | |
|---|---|---|---|---|
| Gender | ||||
| Male | 327 | 68.1 | ||
| Female | 153 | 31.9 | ||
| Age in years | 46.5 | 36–59 | ||
| Chronic disease | 172 | 35.8 | ||
| Diabetes mellitus | 36 | 7.5 | ||
| Hypertension | 39 | 8.1 | ||
| Chronic heart failure | 4 | 0.8 | ||
| Others | 93 | 19.4 | ||
| Unknown | 18 | 3.8 | ||
| Known duration of HBV infection (years) | 5 | 3–9 | ||
| Familial history of Hepatitis B | 185 | 38.5 | ||
| Previous treatment | ||||
| Naive | 105 | 21.9 | ||
| Tenofovir disoproxil fumarate (total) | 340 | 70.8 | ||
| Entecavir | 15 | 3.1 | ||
| Lamivudine | 8 | 1.6 | ||
| Telbivudine | 5 | 1.0 | ||
| Tenofovir disoproxil fumarate + Lamivudine | 8 | 1.6 | ||
| Lamivudine + Entecavir | 3 | 0.6 | ||
| Entecavir + Telbivudine | 4 | 0.8 | ||
| Unknown | 7 | 1.4 | ||
| Interferon history | 73 | 15.2 | ||
| Additional drug usage | 259 | 54.0 | ||
| Use of non-TDF drug affecting BMD | 299 | 62.3 | ||
| Body mass index (kg/m2) | 26.6 | 23.3–29.3 | ||
| HBV DNA | ||||
| Detectable | 78 | 16.3 | ||
| Undetectable | 352 | 73.3 | ||
| Unknown | 50 | 10.4 | ||
| Alanine transaminase | ||||
| Abnormal | 173 | 36.0 | ||
| Normal | 304 | 63.3 | ||
| Unknown | 3 | 0.6 | ||
| Proteinuria | 40 | 8.3 | ||
| White blood cell count (×109/L) | 6.40 | 5.00–7.70 | ||
| Thrombocyte (×109/L) | 217 | 166–268 | ||
| Alanine transaminase (U/L) | 27 | 20–40 | ||
| Aspartate transaminase (U/L) | 27 | 21–36 | ||
| International normalized ratio | 1.10 | 1.00–1.20 | ||
| Total bilirubin (mg/dL) | 0.85 | 0.50–1.20 | ||
| Creatinine (mg/dL) | 0.9 | 0.72–1.04 | ||
| Phosphorus (mg/dL) | 3.0 | 2.6–3.4 | ||
| Albumin (g/dL) | 3.8 | 3.2–4.3 | ||
| Gamma-glutamyl transferase(U/L) | 33 | 22–43 | ||
| Alpha fetoprotein (U/L) | 2.90 | 1.70–3.31 | ||
| eGFR (mL/min/1.73 m2) | 97 | 85–107 | ||
| Lipid profile (mg/dL) | ||||
| Total cholesterol | 180 | 153–210 | ||
| High-density lipoprotein | 48 | 39–59 | ||
| Low-density lipoprotein | 101 | 88–121 | ||
| Hip T score | -1.5 | -2.0– -0.9 | ||
| Spine T score | -2.0 | -3.0– -1.3 |
HBV: Hepatitis B virus; TDF: Tenofovir disoproxil fumarate; eGFR: Estimated glomerular filtration rate; IQR: Interquartile range.