Figure 1.

A-D: Histologic appearance of dura mater consisting of two lamellae of connective tissue. Within the connective tissue there are large and small vessels, which are surrounded by nerve fibres (A-D, neurofilament immunohistochemistry). Nerve fibres are also identified between the lamellae and within the connective tissue (arrows). E-I: Immunohistochemistry for phosphorylated alpha-synuclein at serine 129 and for oligomeric forms with the 5G4 antibody did not show abnormal alpha-synuclein aggregates in most of the studied cases (Fig. 1E, 1F). In one case (case #12 table 1), coarse (G) and punctate (H) aggregates within nerve fibres and perivascular (I) aggregates were identified with the 5G4 antibody.