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. 2020 Feb 12;1:6. doi: 10.17879/freeneuropathology-2020-2616

Table 1.

Demographic and neuropathological features of the study cohort

Case no. Age Gender Synuclein CNS
(1 yes/ 0 no)		 Clinical diagnosis

  • Synuclein pathology in the CNS

  • Synuclein pathology in DMNV/vagus nerve

 Additional neuropathological findings Synuclein in dura
(no.of nerves)		 Abeta patches in dura
1 84 female 1 PD

  • LBD stage 6

  • positive

 AD-NP: A2, B2, C2 negative
(0/n.e.)		 negative
2 85 female 1 vascular risk factors

  • amygdala predominant LBD

  • negative

 AD-NP: A3, B3, C3 negative
(0/49)		 negative
3 84 male 1 vascular risk factors

  • LBD stage 3

  • positive

 PART def + CAA negative
(0/45)		 negative
4 84 male 1 none

  • amygdala predominant LBD

  • negative

 AD-NP: A3, B2, C3 + AGD II negative
(0/36)		 negative
5 85 male 1 stroke, dementia

  • amygdala predominant LBD

  • negative

 AD-NP: A3, B3, C3 + CAA + limbic TDP43 negative
(0/18)		 POSITIVE
6 85 female 1 vascular risk factors

  • LBD stage 2

  • positive

 AD-NP: A1, B2, C1 + AGD II + SVD negative
(0/28)		 negative
7 86 female 1 stroke, vascular epilepsy

  • amygdala predominant LBD

  • negative

 AD -NP: A3, B3, C3 + HS-TDP43 + SVD negative
(0/7)		 negative
8 86 female 1 dementia, vascular risk factors

  • LBD stage 4

  • positive

 AD-NP: A2, B2, C2 + CAA negative
(0/12)		 negative
9 84 male 1 ischaemic cardiomyopathy, AD type dementia

  • amygdala predominant LBD

  • negative

 AD-NP: A3, B3, C3 negative
(0/49)		 negative
10 82 male 1 PD, dementia, vascular leucoencephalopathy

  • LBD stage 5

  • positive

 AD-NP: A2, B2, C1 + vascular negative
(0/7)		 negative
11 83 male 1 stroke, hypertension

  • LBD stage 1

  • positive mild

 AD-NP: A2, B2, C2 + mild CAA + vascular negative
(0/10)		 negative
12 85 male 1 lung carcinoma, ischaemic and restrictive cardiomyopathy

  • LBD stage 4

  • positive

 AD-NP: A2, B1, C1 + vascular POSITIVE
(9/28) 		negative
13 84 female 1 AD type dementia, invasive colon carcinoma

  • MSA

  • Negative, GCI in wm tracts

 MSA + AD-NP: A3, B3, C3 + CAA + TDP43 limbic negative
(0/53)		 POSITIVE
14 85 female 1 metastatic colon carcinoma

  • LBD stage 4

  • positive

 AD-NP: A2, B1, C2 + complex tauopathy + TDP limbic negative
(0/19)		 POSITIVE
15 86 female 1 dementia with psychiatric alterations, oesophagus carcinoma

  • amygdala predominant LBD

  • positive mild

 FTLD-TDP43 type C + AD-NP: A1, B1, C1 negative
(0/33)		 negative
16 84 male 1 stroke, ischaemic cardiomyopathy

  • LBD stage 4

  • positive

 PART def + CAA negative
(0/44)		 negative
17 84 female 0 dementia, ischaemic cardiomyopathy, vascular risk factors, renal carcinoma 0 AD-NP: A3, B3, C3 negative
(0/42)		 negative
18 84 male 0 COPD, empyema, respiratory insufficiency, abd skin melanoma 0 AD-NP: A3, B2, C3 negative
(0/41)		 negative
19 86 female 0 generalized arteriosclerosis, dilatative cardiomyopathy 0 AD-NP: A2, B2, C2 negative
(0/40)		 negative
20 85 female 0 brain contusion after fall, pneumonia, ischaemic cardiomyopathy 0 AD-NP: A3, B2, C2 + CAA + HS-TDP43 negative
(0/12)		 negative
21 85 female 0 dementia, parkinsonism, thyroid carcinoma, pneumonia 0 AD-NP: A3, B3, C3 + CAA negative
(0/6)		 negative
22 87 male 0 ischaemic cardiomyopathy, cardiac insufficiency 0 AD-NP: A3, B3, C3 + CAA negative
(0/17)		 negative
23 86 male 0 cardiomyopathy, hypertension, diabetes, fall with hip fracture 0 AD-NP: A2, B1, C2 + vascular negative
(0/8)		 negative
24 86 male 0 pancreas adenocarcinoma 0 CBD negative
(0/50)		 negative
25 86 female 0 parkinsonism vs PD, diabetes, hypertension, dilatative cardiomyopathy 0 PSP + AD-NP: A2, B2, C2 + CAA negative
(0/67)		 POSITIVE
26 86 female 0 dementia, pacemaker, hypertension, breast carcinoma 0 AD-NP: A2, B2, C2 + AGD II negative
(0/20)		 POSITIVE
27 84 male 0 COPD, dilatative cardiomyopathy 0 AD-NP: A2, B2, C2 + mild CAA + vascular negative
(0/47)		 negative
28 85 male 0 ischaemic cardiomyopathy, diabetes, hypertension 0 AD-NP: A2, B2, C2 + CAA + AGD I negative
(0/n.e.)		 POSITIVE
29 85 female 0 metastatic gastric adenocarcinoma, diabetes, hypertension 0 AD-NP: A3, B3, C3 + CAA negative
(0/34)		 POSITIVE
30 87 male 0 dementia, diabetes, hypertension 0 AD-NP: A3, B2, C2 + CAA + AGD II negative
(0/n.e.)		 negative
31 87 female 0 AD type dementia, diabetes, nephropathy 0 AD-NP: A2, B2, C2 + mild CAA negative
(0/38)		 POSITIVE
32 83 male 0 COPD, cardiomyopathy, traumatic spinal cord injury, pneumonia 0 AD-NP: A3, B3, C3 + CAA + limbic TDP43 negative
(0/54)		 negative

Abbreviations: AD: Alzheimer’s disease; PD: Parkinson’s disease; COPD: chronic obstructive pulmonary disease; AD-NP: Alzheimer’s disease neuropathological changes; CAA: cerebral amyloid angiopathy; AgD: argyrophilic grain disease; HS: hippocampal sclerosis; PART: primary age-related tauopathy; SVD: small vessel disease; CBD: corticobasal degeneration. n.a.: not available; n.e.: not evaluable due to unsteady immunoreactivity