Table 4. Post-mortem neuropathological findings.
CAA = cerebral amyloid angiopathy, APOE = apolipoprotein E, NA = not available, ADNC = Alzheimer’s disease neuropathological change (NIA-AA [24]), PART = primary age-related tauopathy, PSP = progressive supranuclear palsy, CBD = corticobasal degeneration, Aβ = Amyloid-β deposition, ICH = Intracerebral hematoma, SAH = subarachnoidal hematoma, SDH = subdural hematoma.
| Cognitive status at death | n | Sex | Age at death ± (SD) | Brain weight (g) | CAA (n) | APOE | Neurodegenerative lesions | Cerebrovascular pathology contributing to cognitive status | Other cerebrovascular lesions | |
|---|---|---|---|---|---|---|---|---|---|---|
| ADNC | Non-ADNC | |||||||||
| Normal or mild cognitive impairment (MCI) | 11 | M 3 F 8 | 73±9 | 1413±19 | 1/11 | 10/11 ε3/3 (8/10) ε4/3 (1/10) ε3/2 (1/10) 1 NA | Low (3/11) Intermediate (1/11) High - | PART 6/11 PSP 1/11 | Cerebrovascular atherosclerosis 5/11 Infarct(s) 4/11 | Postoperative ICH (2/11) SAH (1/11) Acute SDH (1/11) |
| Moderate dementia | 9 | M 5 F 4 | 73±7 | 1428±17 | 2/9 | 3/9 ε4/3 (2/3) ε3/3 (1/3) | Low - Intermediate (3/9) High - | PART 4/9 | Cerebrovascular atherosclerosis (5/9) Infarct(s) (2/9) | Acute SDH (4/9) SAH (1/9) |
| Severe dementia | 9 | M 4 F 5 | 76±5 | 1349±19 | 4/9 | 2/9 ε3/3 (1) ε4/4 (1) | Low (4/9) Intermediate (1/9) High (1/9) | PART 2/9 CBD 1/9 PSP 1/9 Aβ 1/9 Synucleinopathy 1/9 | Infarct(s) 4/9 Cerebrovascular atherosclerosis (9/9) |