Skip to main content

Table 5. Neuropathological findings in NPH.

NPH = normal pressure hydrocephalus, NA = not available, AD = Alzheimer’s disease.

Neuropathological findings in NPH Previous pooled studies (reviewed by Leinonen et al. 2012) Cabral 2011 Magdalinou 2013 Del Bigio 2014 McCarty 2019 Present study
Total number of cases 40 9 4 28 1 post-mortem 29
Idiopathic NPH 55% NA 0% 18% Yes 58%
Cortical atrophy 43% No 45%
Meningeal thickening 64% Yes 60%
Subependymal gliosis 60% Yes 77%
Periventricular white matter demyelination 60% 48%
Vascular changes 76% 33% 75% 65%
AD-changes 48% 89% No 48%