Table 5. Neuropathological findings in NPH.
NPH = normal pressure hydrocephalus, NA = not available, AD = Alzheimer’s disease.
| Neuropathological findings in NPH | Previous pooled studies (reviewed by Leinonen et al. 2012) | Cabral 2011 | Magdalinou 2013 | Del Bigio 2014 | McCarty 2019 | Present study |
|---|---|---|---|---|---|---|
| Total number of cases | 40 | 9 | 4 | 28 | 1 post-mortem | 29 |
| Idiopathic NPH | 55% | NA | 0% | 18% | Yes | 58% |
| Cortical atrophy | 43% | No | 45% | |||
| Meningeal thickening | 64% | Yes | 60% | |||
| Subependymal gliosis | 60% | Yes | 77% | |||
| Periventricular white matter demyelination | 60% | 48% | ||||
| Vascular changes | 76% | 33% | 75% | 65% | ||
| AD-changes | 48% | 89% | No | 48% |