Table 3:
Baseline Characteristics and Descriptive Statistics of Outcome Measures of population replicating Kang et al. 2019 methodology30
| Before Matching | After Matching | |||||
|---|---|---|---|---|---|---|
| Variable | Non-Statin User (N = 318813) | Statin User (N = 152957) | SMD | Non-Statin User (N = 287186) | Statin User (N = 152957) | SMD |
| Gender | 0.036 | 0.004 | ||||
| Female | 147928 (46.4%) | 68256 (44.6%) | 128670 (44.8%) | 69256 (44.6%) | ||
| Male | 170885 (53.6%) | 84701 (55.4%) | 158516 (55.2%) | 84701 (55.4%) | ||
| Age at baseline Mean (SD) | 65.77 (10.42) | 65.91 (10.05) | 0.014 | 65.4 (10.4) | 65.9 (10.1) | 0.047 |
| Office Visits Mean (SD) | 3.71 (4.19) | 3.99 (4.37) | 0.066 | 3.77 (4.23) | 3.99 (4.37) | 0.053 |
| Hypertension diagnosis with HTN drug use at baseline | 88559 (27.8) | 44461 (29.1) | 0.029 | 78925 (27.5%) | 44461 (29.1%) | 0.035 |
| Ischemic heart disease at baseline | 35398 (11.1) | 29978 (19.6) | 0.237 | 35379 (12.3%) | 29978 (19.6%) | 0.200 |
| Chronic kidney disease at baseline | 28679 (9.0) | 15168 (9.9) | 0.031 | 25368 (8.8%) | 15168 (9.9%) | 0.037 |
| Ischemic stroke at baseline | 14601 (4.6) | 10215 (6.7) | 0.091 | 14421 (5.0%) | 10215 (6.7%) | 0.071 |
| Heart failure at baseline | 14276 (4.5) | 9710 (6.3) | 0.083 | 13628 (4.7%) | 9710 (6.3%) | 0.070 |
| Peripheral arterial disease at baseline | 17666 (5.5) | 10233 (6.7) | 0.048 | 15741 (5.5%) | 10233 (6.7%) | 0.051 |
| Severity of diabetic disease at baseline | 0.017 | 0.032 | ||||
| No disease | 288826 (90.6) | 138263 (90.4) | 262124 (91.3%) | 138263 (90.4%) | ||
| Diabetic neuropathy | 23315 (7.3) | 11129 (7.3) | 19338 (6.7%) | 11129 (7.3%) | ||
| Diabetic foot | 6029 (1.9) | 3190 (2.1) | 5135 (1.8%) | 3190 (2.1%) | ||
| Amputation | 643 (0.2) | 375 (0.2) | 589 (0.2%) | 375 (0.2%) | ||
| Charleson Comorbidity Index at baseline | ||||||
| Mean (SD) | 1.79 (1.86) | 1.86 (2.03) | 0.033 | 1.73 (1.84%) | 1.86 (2.03%) | 0.067 |
| Outcome Measures | ||||||
| DR | 24961 (7.8) | 14707 (9.6) | 0.063 | 24961 (8.7%) | 14707 (9.6%) | 0.032 |
| NPDR | 18416 ( 5.8) | 10800 (7.1) | 0.052 | 18416 (6.4%) | 10800 (7.1%) | 0.026 |
| Proliferative DR | 1656 (0.5) | 871 (0.6) | 0.007 | 1656 (0.6%) | 871 (0.6%) | 0.001 |
| DME | 3669 (1.2) | 2061 (1.3) | 0.018 | 3669 (1.3%) | 2061 (1.3%) | 0.006 |
| Vitreous heme | 1493 (0.5) | 849 (0.6) | 0.012 | 1493 (0.5%) | 849 (0.6%) | 0.005 |
| TRD | 588 (0.2) | 343 (0.2) | 0.009 | 588 (0.2%) | 343 (0.2%) | 0.004 |