TABLE 2.
Summar of the difference between non-hiPSC-CM and hiPSC-CM cells.
| Non-hiPSC-CM | hiPSC-CM | |
|---|---|---|
| Pathway | • Suppression of Wnt/β-catenin | • Suppression of Wnt/β-catenin |
| • Dysregulation of HIPPO/YAP pathway | • Dysregulation of HIPPO/YAP pathway | |
| • Upregulation of PPARγ | • Upregulation of PPARγ | |
| • Implication of NF-κB | ||
| • Pro-inflammatory implication | ||
| Morphology | • Desmosome Destabilization | • Desmosome Destabilization |
| • Lipid Accumulation | • Lipid Accumulation | |
| • Apoptosis | • Apoptosis | |
| • Transdifferentiation | ||
| Electrophysiology | • Reduced Nav1.5 current | • Reduced Nav1.5 current |
| • Shortened Action Potential Duration | ||
| • Decrease of Cx43 gene expression | • Increase in global potassium currents | |
| • Decrease and defect contractile function | ||
| • Calcium handling disturbance | ||
| Therapy | • Combination of Sotalol and Flecainide | |
| • Spironolactone |