Figure 9.

Boiled-egg diagram for all the afforded compounds as well as ciprofloxacin as a reference control, where points located in the boiled-egg’s yolk are molecules anticipated to pass through the blood brain barrier, points located in the boiled-egg’s white are molecules anticipated to be passively absorbed from GIT, blue dots are molecules predicted to be effluated from CNS by P-glycoprotein, and red dots are molecules predicted not to be effluated from CNS by P-glycoprotein.