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. Author manuscript; available in PMC: 2023 Aug 10.
Published in final edited form as: Nat Ment Health. 2023 May 10;1(5):304–315. doi: 10.1038/s44220-023-00057-5

Table 1 |.

Sources of imprecision in psychopathology phenotyping and proposed solutions

Problem Solution
Sampling bias Dimensional sampling and measurement
Minimal and inconsistent phenotyping Deep phenotyping and use of standardized measures
Phenotypic complexity Use of homogeneous unidimensional scales, test for multidimensionality and model hierarchical relations between dimensional constructs
Poor phenotypic resolution Increase phenotypic resolution by adding items assessing the adaptive end of the continuum
Measurement non-invariance Test for and accommodate measurement invariance
The heterogeneity problem
Person-centered heterogeneity Mixture modeling
Variable-centered heterogeneity Broadband assessment of psychopathology and hierarchical modeling
Method bias Multi-method assessment