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. Author manuscript; available in PMC: 2023 May 25.
Published in final edited form as: Cell Rep. 2023 Mar 14;42(3):112237. doi: 10.1016/j.celrep.2023.112237

Figure 2. Loss of Jarid2 promotes extended production of early-born retinal neurons.

Figure 2.

Animals were administered EdU at E18.5 and analyzed at P0 (G). Six3-Cre Jarid2 cKO but not control retinas showed EdU-labeled (A, B, and I) Brn3a+ RGCs, (C, D, and J; p = 0.08) Oc2+ horizontal cells, and (E, F, and K) Rxrγ+ cone photoreceptors. (H) Cell-cycle exit (EdU+PCNA−/EdU+) of RPCs was increased in Six3-Cre Jarid2 cKO retina. Zoomed-in images were obtained from a single imaging plane. Graphs represent mean ± SEM, n = 6. **p < 0.01, ***p < 0.00 by Student’s t test. Scale bars, 100 μm. See also Figure S3 and Table S6 for statistical details.