Table 2.

Univariate meta-regression analysis for the effects of n-3 PUFA on joint pain in patients with OA

Covariate	Pain
	Coefficient	95% CI	p
Patient number	0.0003	− 0.0001 to 0.0007	0.16
Mean age (years)	0.031	− 0.012 to 0.073	0.13
Men (%)	0.0092	− 0.0117 to 0.0301	0.33
n-3 PUFA dose (mg/d)	− 0.0002	− 0.0006 to 0.0002	0.21
EPA dose (mg/d)	0.0001	− 0.0012 to 0.0014	0.82
DHA dose (mg/d)	− 0.0003	− 0.0007 to 0.0001	0.18
Follow-up duration (months)	0.005	− 0.003 to 0.013	0.18

CI confidence interval; n-3 PUFA omega-3 polyunsaturated fatty acids; OA osteoarthritis; EPA eicosapentaenoic acid; DHA docosahexanoic acid