Table 3.
The most incorrectly answered questions in DBTs with the most mistakes done
| DBT No | Question No |
Incorrect Responses (%) | Question |
|---|---|---|---|
| DBT1 | 1 | 46 (41.1) | Phase 1 studies are mainly efficacy studies |
| 2 | 8 (7.1) | A drug candidate can be directly investigated in human studies without testing in animals | |
| 3 | 58 (51.8) | The LD50 is detected in phase 2 studies | |
| 4 | 15 (13.4) | If the Phase 4 study is successful, a drug license application is made | |
| DBT5 | 1 | 33 (29.5) | The purpose of drug metabolism is to make the drug more lipophilic |
| 2 | 35 (31.3) | The oxidation carried out by microsomal enzymes in the liver is the second phase reaction | |
| 3 | 13 (11.6) | The cytochrome P450 enzyme that metabolizes 50% of all drugs is CYP3A4/5 | |
| 4 | 69 (61.6) | Chronic alcohol intake causes CYP enzyme inhibition | |
| DBT6 | 1 | 3 (2.7) | Most of the drugs are eliminated by first order kinetics |
| 2 | 37 (33.0) | The elimination rate of drugs eliminated with first order kinetics is independent of the plasma concentration | |
| 3 | 32 (28.6) | In the first order kinetics, a constant amount of the drug is eliminated per unit of time | |
| 4 | 25 (22.3) | In the zero-order kinetics, the half-life remains constant | |
| DBT7 | 1 | 52 (46.4) | The inactivation of an acidic drug with a basic drug is pharmacological antagonism |
| 2 | 6 (5.4) | The type of antagonism seen between a vasoconstrictor drug and a vasodilator drug is physiological antagonism | |
| 3 | 17 (15.2) | The main effect of the non-competitive antagonist is to reduce the efficacy of the agonist | |
| 4 | 31 (27.7) | A competitive antagonist does not alter the efficacy of the agonist, but increases its potency | |
| DBT8 | 1 | 84 (75.0) | A plasma concentration time curve is drawn to demonstrate the potency of an agonist drug |
| 2 | 31 (27.68) | The smaller the EC50 of a drug, the higher its efficacy | |
| 3 | 85 (75.9) | A gradual dose response curve is used when the drug effect is all or none | |
| 4 | 8 (7.14) | The greater the therapeutic index value of a drug, the safer it is | |
| DBT9 | 1 | 50 (44.6) | The ability to activate the receptor after binding to the receptor is called affinity |
| 2 | 74 (66.1) | An antagonist is a drug that affects in the opposite direction by binding to the receptor | |
| 3 | 7 (6.3) | A partial agonist is a drug that has an agonist-like effect if used alone and reduces the agonist’s effect if used together with an agonist | |
| 4 | 21 (18.8) | The drug with negative intrinsic activity is an inverse agonist | |
| DBT10 | 1 | 17 (15.2) | If an agonist has produced maximum effect, it always means that it binds to all receptors |
| 2 | 0 (0) | The substance that selectively binds to a receptor is called ligand | |
| 3 | 4 (3.6) | In the absence of spare receptors, the concentration that produces half the maximum effect is equal to the concentration required to bind half of all receptors | |
| 4 | 54 (48.2) | Endogenous ligands are always agonists | |
| DBT11 | 1 | 14 (12.5) | No secondary messenger is used in G-protein coupled receptor-mediated signaling |
| 2 | 60 (53.6) | Gs type G-protein activates phospholipase C | |
| 3 | 19 (16.7) | Gq type G-protein activation causes an increase in intracellular calcium | |
| 4 | 24 (21.4) | Bronchodilation is seen as a result of adenylate cyclase activation and cyclic AMP increase with a Gs type G-protein mediated effect | |
| DBT12 | 1 | 25 (22.3) | Adrenergic and muscarinic receptors are G-protein coupled receptors |
| 2 | 51 (45.5) | Nicotinic receptors are G-protein coupled receptors | |
| 3 | 12 (10.7) | The insulin receptor is a tyrosine kinase receptor | |
| 4 | 19 (17.0) | Thyroid hormone receptor is in the nucleus | |
| DBT14 | 1 | 9 (8.0) | Beta lactam antibiotics are safe during pregnancy |
| 2 | 15 (13.4) | Piperacillin is administered only orally | |
| 3 | 57 (50.9) | Sulbactam inhibits transpeptidase enzyme | |
| 4 | 7 (6.3) | Aztreonam can be used in patients with penicillin allergy | |
| DBT15 | 1 | 12 (10.7) | Penicillins are bacteriostatic |
| 2 | 38 (33.9) | Penicillins reversibly inhibit the transpeptidase enzyme | |
| 3 | 4 (3.6) | The main mechanism of penicillin resistance is the production of beta-lactamase enzyme by the bacteria | |
| 4 | 66 (58.9) | Excretion of penicillins occurs by glomerular filtration | |
| DBT16 | 1 | 27 (24.1) | Ceftaroline is the only effective cephalosporin for MRSA |
| 2 | 62 (55.4) | Cefepime can cross the blood brain barrier but is unstable to beta-lactamase | |
| 3 | 12 (10.7) | Ceftazidime is effective against Pseudomonas aeruginosa | |
| 4 | 4 (3.6) | Cefazolin is the most commonly used cephalosporin in surgical prophylaxis |