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. 2023 May 24;11:85. doi: 10.1186/s40478-023-01580-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Identification of a pro-regenerative gene signature in monocyte-derived macrophages. A Top ligands of each macrophage cluster were selected and ranked based on their ligand activity values. Each ligand was assigned to a cluster if it was expressed highest in this cluster compared to the remaining sender clusters. The colour (white, low expression; orange, high expression) represents the predicted activity of the ligands. The expression of the top ligands in each cluster is shown with the colour (blue, low expression; red, high expression) representing the scaled average expression in the corresponding cluster. B Circle plot of potential ligand-receptor pairs, that shows the links between predicted ligands from MDM cluster 7 with their associated receptors found on alpha- and intrinsically photosensitive retinal ganglion cells