Table 3.
Results of univariate analysis identifying variables that differed significantly between the good and unfavorable outcome groups
| Variable | Good (n = 60) | Unfavorable (n = 96) | Pvalue | Logistic regression | ||
|---|---|---|---|---|---|---|
| B | OR (95% CI) | p value | ||||
| Gender (male) | 34 | 61 | 0.392* | -0.287 | 0.750(0.388,1.449) | 0.392 |
| Age at onset (years) | 46.5(36.3,56.0) | 50.0(43.0,64.0) | 0.021 | 0.030 | 1.031(1.007,1.055) | 0.010 |
| Interval from onset to antifungal treatment(day) | 29.0(15.0,39.0) | 34.5(18.3,63.8) | 0.082 | 0.007 | 1.007(0.999,1.014) | 0.095 |
| Duration of antifungal treatment(day) | 23.0(13.0,44.0) | 16.5(8.0,39.0) | 0.131 | -0.003 | 0.997(0.987,1.007) | 0.554 |
| Am B administration | 57 | 91 | > 0.999* | -0.043 | 0.958(0.220,4.163) | 0.954 |
| Ventriculoperitoneal shunt placement | 3 | 19 | 0.010 * | 1.545 | 4.688(1.323,16.609) | 0.017 |
| Meningeal irritation positive | 18 | 44 | 0.098* | 0.680 | 1.974(0.998,3.908) | 0.051 |
| CSF pressure (> 180mmH2O) | 49 | 78 | 0.948* | 0.028 | 1.028(0.448,2.359) | 0.948 |
| Blood WBC count(109/L) | 7.8(5.8,10.8) | 8.4(5.6,12.3) | 0.457 | 0.028 | 1.028(0.955,1.108) | 0.462 |
| CSF WBC count(106/L) | 65.0(20.0,165.8) | 50.0(18.0,121.3) | 0.412 | -0.001 | 0.999(0.998,1.001) | 0.328 |
| CSF Glucose(mmol/L) | 2.5(1.7,2.9) | 1.8(0.9,2.9) | 0.037 | -0.118 | 0.889(0.701,1.128) | 0.332 |
| CSF Chloride (mmol/L) | 118.7(115.6,122.3) | 117.3(113.6,121.3) | 0.342 | -0.019 | 0.981(0.938,1.027) | 0.410 |
| CSF Protein (g/L) | 0.85(0.53,1.33) | 0.93(0.52,1.55) | 0.600 | 0.193 | 1.213(0.776,1.896) | 0.397 |
| Parenchymal lesions | 28 | 41 | 0.669* | -0.142 | 0.868(0.453,1.662) | 0.669 |
| Meningeal enhancement | 11 | 30 | 0.091* | 0.705 | 2.025(0.925,4.433) | 0.078 |
| Hydrocephalus | 5 | 14 | 0.236* | 0.643 | 1.901(0.648,5.582) | 0.242 |
| GCS score(<15) | 1 | 25 | <0.001 * | 3.034 | 20.775(2.733,157.924) | 0.003 |
| Immunocompromised condition | 10 | 39 | 0.002 * | 1.230 | 3.421(1.550,7.551) | 0.002 |
Data are expressed as n (%) or median (interquartile range); Statistical analysis rank sum test unless otherwise specified; *chi-square test; Bold denotes statistical difference; Am B: Amphotericin B; CSF: cerebrospinal fluid; GCS score : Glasgow Coma Scale score; WBC: white blood cell; CSF: cerebrospinal fluid; B:Regression coefficient;OR: Odds ratio; CI: Confidence interval