Table 1.
Severe perinatal complications in cases of large placental chorioangiomas
| Case | GA at delivery/weeks | Maternal complications | Fetal complications | Pregnancy/Children Outcome | |
|---|---|---|---|---|---|
| 1 | Singleton | 32+ 3 | Mirror syndrome, Polyhydramnios | Fetal hydrops | Iatrogenic lethal induction of labor |
| 2 | Twin pregnancy | 34+ 3 | - | Fetal cardiomegaly, Fetal hydrops, Fetal distress, PTB | NICU admission (7 days/28 days), Normal development |
| 3 | Singleton | 33+ 6 | PPROM | Fetal cardiomegaly (transplacental digoxin intervention), Fetal anemia, PTB | NICU admission (13 days), NIH (grade III), Normal development |
| 4 | Singleton | 25+ 4 | Polyhydramnios | Fetal cardiomegaly, Fetal hydrops | Patient asked for lethal induction of labor |
| 5 | Singleton | 25 | - | Fetal cardiomegaly, Fetal hydrops, Fetal anemia, IUD | |
| 6 | Singleton | 28+ 4 | Polyhydramnios, PPROM | PTB | Stillbirth during labor |
| 11 | Singleton | 28+ 4 | Polyhydramnios, PPROM | Fetal hydrops, Fetal anemia, PTB | NICU admission (61 days), NIH (grade II) and secondary hydrocephalus, Poor performance of left-hand fine motor functions |
| 15 | Singleton | 27+ 2 | Polyhydramnios (amnioreduction intervention), | PTB | Stillbirth during labor |
| 18 | Singleton | 29+ 4 | Polyhydramnios | PTB | NICU admission (46 days), NIH (grade IV), Claudication of the left lower extremity, BPD, infantile cutaneous hemangioma, Transient renal function damage |
| 19 | Twin pregnancy | 31+ 5 | Polyhydramnios, PPROM, Placental abruption | PTB | NICU admission (36 days/32 days), Normal development |
| 21 | Singleton | 29+ 3 | Polyhydramnios, PPROM and chorioamnionitis | Fetal anemia, PTB | NICU admission (2 days), Neonatal shock, NND |
| 23 | Singleton | 38+ 2 | Polyhydramnios (amnioreduction and oral indomethacin intervention) | - | Normal development |
| 24 | Singleton | 38+ 1 | - | IUD | |
| 28 | Singleton | 33+ 3 | Polyhydramnios, PPROM, PPH | Fetal hydrops, fetal abnormality | Iatrogenic lethal induction of labor |
| 42 | Singleton | 37 | Polyhydramnios | IUD | |
* GA: gestational age; PTB: preterm birth; NICU: neonatal intensive care unit; PPROM: preterm premature rupture of membrane; NIH: neonatal intracranial hemorrhage; IUD: intrauterine death; NND: neonatal death; BPD: bronchopulmonary dysplasia; PPH: postpartum hemorrhage.