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. 2023 May 24;21:123. doi: 10.1186/s12915-023-01612-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Regulation of species-specific gene expression by species-specific H3K4me3 and H3K27ac peaks. A, C Summary of the species-specific expressed genes detected in the RNA-seq dataset (A) and ssRNA-seq dataset (C). The pink and purple denote upregulated and downregulated genes specific to primates, respectively. The silhouette denotes primate identity throughout the figure (red, human; blue, chimpanzee; green, macaque). Digits in areas denote the number of genes. B, D Proportion of species-specific expressed genes regulated by species-specific H3K4me3 peaks (orange) and H3K27ac peaks (light orange) in the RNA-seq (B) and ssRNA-seq (D) datasets. The y-axis displays percentile values. C, D (n = 3) (See replicate data in Additional file 1: Table S13)