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. 2023 May 8;17(10):9178–9187. doi: 10.1021/acsnano.2c12755

Figure 1.

Figure 1

A. Molecular scheme for specific enzymatic DNA labeling using EcoDam MTase and a fluorescent cofactor. B. Schematic representation of the method concept from nuclei to dual labeled molecules. C. Representative field of view of dually labeled molecules. D. Genome browser view of a 260 Kbp region on chromosome 1, top to bottom; cytoband map; Hg38 genomic coordinates; predicted genetic sites; digitized representation of the mapped molecules to Hg38 according to their genetic labeling; Hg38 known genes locations; GM12878 cell-line known promoter locations; normalized DAFCA-OGM. Peaks of the DAFCA track that overlap with promoters are highlighted in orange circles, indicating highly accessible chromatin.