Figure 3:

The mediation analysis results for the data example. The mediation variable is systolic blood pressure (SBP). (a) is the heatmap of $-\text{log}\left(p\right)$-matrix based on the input data. (b) is the heatmap with detected systematic mediation patterns. (c) is the mediation results based on the mediating factor. $\beta$ and $\theta$ effects are averaged across related outcome ROIs. Overall, the mediation proportion is high.