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A model for Rep-mediated inhibition of E2 activity. The N-terminal activation domain of 16E2 recruits the transcriptional coactivator p300 through its KIX domain (35). AAV2 Rep proteins that bind 16E2 specifically disrupt this interaction. Rep-mediated squelching of the 16E2-p300 interaction accounts for the inhibition of E2-mediated transactivation and HPV16 replication.
