TABLE 2.
Sensitivities of HSV-1, HSV-2, and purified viral proteins to modified heparin compounds
| Prepn | IC50 (μg/ml)
|
|||
|---|---|---|---|---|
| Heparin | N-desulfated heparin | 2-O-desulfated heparin | 6-O-desulfated heparin | |
| HSV-1, 37°C | 0.4 | 5 (13a) | 60 (150) | 30 (75) |
| HSV-2, 37°C | 0.1 | 0.8 (8) | 5 (50) | 3 (30) |
| HSV-1, 4°C | 0.3 | 5 (17) | 30 (100) | 10 (33) |
| HSV-2, 4°C | 0.09 | 0.6 (7) | 2 (22) | 1 (11) |
| gB-1 | 0.4 | 10 (25) | 50 (125) | 60 (150) |
| gB-2 | 0.1 | 0.9 (9) | 0.9 (9) | 1 (10) |
| gC-1 | 2 | 3 (2) | 10 (5) | 40 (20) |
| gC-2 | 0.8 | 3 (4) | 10 (13) | 10 (13) |
a
Ratio of modified heparin to native heparin.