Table 4.
Presence of antimicrobial resistance markers of the sequenced Shigella isolates by species (n=109), stratified by men who have sex with men (MSM) and females and males who do not have sex with men
|
No or unkown MSM association |
MSM-associated |
|||||
|---|---|---|---|---|---|---|
|
S. sonnei (n=36) |
S. dysent. |
|||||
|
(n=24) |
(n=1) |
(n=1) |
(n=19) |
(n=28) |
||
|
Quinolone |
12 (33 %) |
8 (33 %) |
0 |
0 |
17 (89 %)* |
5 (18 %) |
|
gyrA p.S83L† |
12 |
2 |
– |
– |
17 |
2 |
|
gyrA p.D87G† |
8 |
1 |
– |
– |
15 |
0 |
|
parC p.S80I† |
9 |
2 |
– |
– |
15 |
1 |
|
qnrS1‡ |
0 |
6 |
– |
– |
0 |
4 |
|
≥1 PM/gene |
12 |
8 |
– |
– |
17 |
5 |
|
≥3 PM/gene |
8 |
1 |
– |
– |
15 |
0 |
|
Aminoglycoside |
35 (97 %) |
19 (79 %) |
1 (100 %) |
1 (100 %) |
19 (100 %) |
28 (100 %)* |
|
aadA1 |
11 |
13 |
1 |
1 |
4 |
27 |
|
aadA5 |
5 |
1 |
0 |
0 |
10 |
3 |
|
aph(6)-Id (strB) |
28 |
8 |
1 |
0 |
16 |
2 |
|
aph(3’)-Ib (strA) |
34 |
9 |
1 |
0 |
17 |
3 |
|
Macrolide |
6 (17 %) |
1 (4 %) |
0 |
0 |
11 (58 %)* |
12 (43 %)* |
|
erm(B) |
6 |
1 |
– |
– |
10 |
9 |
|
mph(A) |
6 |
1 |
– |
– |
11 |
11 |
|
Sulphonamide |
33 (92 %) |
9 (38 %) |
1 (100 %) |
0 |
19 (100 %) |
7 (25 %) |
|
sul1 |
5 |
0 |
0 |
– |
10 |
6 |
|
sul2 |
33 |
9 |
1 |
– |
18 |
4 |
|
Trimethoprim |
35 (97 %) |
15 (63 %) |
1 (100 %) |
0 |
19 (100 %) |
18 (64 %) |
|
dfrA1 |
34 |
10 |
1 |
– |
19 |
13 |
|
dfrA5 |
0 |
0 |
0 |
– |
0 |
2 |
|
dfrA7 |
0 |
1 |
0 |
– |
0 |
0 |
|
dfrA14 |
1 |
4 |
0 |
– |
1 |
1 |
|
dfrA17 |
5 |
0 |
0 |
– |
10 |
5 |
|
Tetracyline |
25 (69 %) |
19 (79 %) |
1 (100 %) |
1 (100 %) |
16 (84 %) |
27 (96 %) |
|
tet(A) |
25 |
6 |
1 |
0 |
16 |
0 |
|
tet(B) |
0 |
14 |
0 |
1 |
1 |
27 |
|
Beta-lactam |
7 (19 %) |
18 (75 %) |
0 |
1 (100 %) |
10 (53 %)* |
28 (100 %) |
|
ESBL |
1 (3 %) |
13 (54 %) |
0 |
1 (100 %) |
3 (16 %) |
28 (100 %)* |
|
bla TEM-1B |
6 |
6 |
– |
0 |
8 |
4 |
|
bla OXA-1 |
0 |
13 |
– |
1 |
0 |
27 |
|
bla CTX-M-27 |
1 |
0 |
– |
0 |
3 |
1 |
|
Phenicol |
0 |
13 (54 %) |
0 |
1 (100 %) |
0 |
26 (93 %)* |
|
catA1 |
– |
12 |
– |
1 |
0 |
26 |
|
floR |
– |
1 |
– |
0 |
0 |
0 |
*Significantly higher AMR in MSM-associated isolates (P ≤0.005).
†Chromosomal.
‡Plasmidal.
PM, point mutation.