Fig. 3.
Phylogeny of M1UK, M1global and two intermediate sublineages. Maximum likelihood phylogenetic tree reconstructed from core SNPs (without recombination regions) of 269 invasive and non-invasive emm1 S. pyogenes isolate genomes representative of four main groups (M1global, M113SNPs, M123SNPs, M1UK). The phylogenetic tree is coloured as described in the key. White bubbles represent isogenic strains from two distinct outbreaks with 26 and 22 SNPs, respectively, and one invasive isolate with 19 SNPs. Isolate whole genome sequences used in the phylogenetic tree are listed in Table S2.