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. 2023 May 25;14:3026. doi: 10.1038/s41467-023-38783-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Neonatal K18-hACE2^+/- mice were infected with indicated SARS-CoV-2 and viral shedding samples were collected daily. At 2 dpi, retrotracheal lavages and lungs were collected to determine viral titers and heads were fixed for immunohistochemistry. b–g Viral burden in daily shedding samples (left) and at 2 dpi in shedding samples, upper respiratory tract and lungs (right). Individual values below the limit of detection (LOD, 50 PFU/ml) were set to 5. Data from at least 2 independent repetitions with n = 6 - 15 pups per group. Only significant p-values (Kruskal-Wallis test) are presented. h Immunohistochemistry for SARS-CoV-2 N at 2 dpi in nasopharynx. Created with BioRender.com.