Table 3.
Associations between depression symptom trajectory estimates and cortical thickness – main effects and moderation by sex.
|
Left Hemisphere
|
Right Hemisphere
|
|||||||
|---|---|---|---|---|---|---|---|---|
| Lateral OFC | Medial OFC | Lateral OFC | Medial OFC | |||||
| Est (SE) | Est (SE) | Est (SE) | Est (SE) | Est (SE) | Est (SE) | Est (SE) | Est (SE) | |
| Age at Scan | −.028 (.021) | −.031 (.020) | .014 (.022) | .020 (.021) | −.031 (.028) | −.031 (.029) | .017 (.030) | .016 (.031) |
| Child Sex | .054 (.045) | .068 (.044) | −.051 (.048) | −.049 (.045) | .013 (.061) | .019 (.062) | −.062 (.066) | −.051 (.066) |
| MH MDD | −.038 (.044) | −.032 (.041) | .031 (.046) | .044 (.043) | .001 (.058) | .006 (.059) | −.052 (.063) | −.045 (.063) |
| CDI Int. | −.008 (.006) | −.010 (.007) | −.012 (.006) | −.004 (.008) | −.007 (.008) | −.006 (.011) | −.009 (.008) | −.010 (.011) |
| Sex X Int. | -- | .011 (.017) | -- | .032 (.018) | -- | −.002 (.025) | -- | .010 (.026) |
| CDI Slope | −.002 (.016) | .004 (.011) | .006 (.017) | −.019 (.012) | −.013 (.021) | −.003 (.016) | −.004 (.023) | .001 (.017) |
| Sex X Slope | -- | −.081*(.035) | -- | −.111**(.037) | -- | −.056 (.051) | -- | −.080 (.054) |
| Constant | 2.870**(.035) | 3.400**(.353) | 2.671**(.037) | 2.305**(.369) | 2.849**(.047) | 3.378**(.506) | 2.780**(.051) | 2.495**(.538) |
| Observations | ||||||||
| Observations | 52 | 52 | 52 | 52 | 52 | 52 | 52 | 52 |
| R2 | .134 | .260 | .144 | .290 | .043 | .073 | .046 | .103 |
| Adjusted R2 | .040 | .143 | .051 | .177 | −.061 | −.075 | −.058 | −.040 |
| Residual SE | .145 | .137 | .153 | .143 | .194 | .195 | .209 | .208 |
| F | 1.422a | 2.213b | 1.553a | 2.570b* | .416a | .491b | .443a | .719b |
*
p < .05
**
p < .01
a
Model degrees of freedom = 5, 46
b
Model degrees of freedom = 7, 44.
Note: OFC = Orbitofrontal Cortex; CDI = Children’s Depression Inventory; Int. = Intercept, centered at age 12; MH MDD = Maternal History of MDD; MH MDD was coded as a factor variable with No Maternal MDD as the reference category; Sex was coded as a factor variable with Male as the reference category