Table 2. Clinical test results and acute physiology of study population at continuous renal replacement therapy (CRRT) initiation.
| Parameter | All patients (n = 612) mean ± SD | Survivors (n = 167) mean ± SD | Non-survivors (n = 445) mean ± SD | p-value |
|---|---|---|---|---|
| Serum creatinine (mg/dL) | 3.1 ± 1.9 | 3.8 ± 2.4 | 2.9 ± 1.8 | <0.001** |
| BUN (mg/dL) | 57.8 ± 33.8 | 61.8 ± 37.4 | 56.5 ± 32.6 | 0.236** |
| Urine volume (mL/day) | 759 ± 1003 | 1169.9 ± 1244.9 | 634.0 ± 898.4 | <0.001** |
| Hb (g/dL) | 9.9 ± 2.2 | 10.0 ± 2.1 | 9.9 ± 2.3 | 0.615* |
| WBC count (x10 3 /μL) | 14.5 ± 9.9 | 15.3 ± 9.2 | 14.4 ± 10.3 | 0.092** |
| Lactic acid (mmol/L) | 7.3 ± 6.1 | 4.9 ± 4.9 | 8.2 ± 6.3 | <0.001** |
| CRP (mg/L) | 125.6 ± 112.3 | 117.7 ± 102.8 | 128.9 ± 115.6 | 0.373** |
| Arterial pH | 7.2 ± 0.14 | 7.4 ± 0.1 | 7.3 ± 0.1 | <0.001** |
| Arterial bicarbonate (mmol/L) | 16.5 ± 5.6 | 17.3 ± 5.9 | 16.2 ± 5.5 | 0.039* |
| Total bilirubin (mg/dL) | 3.4 ± 7.1 | 3.2 ± 8.3 | 3.5 ± 6.5 | <0.001** |
| INR | 1.7 ± 1.1 | 1.5 ± 0.9 | 1.8 ± 1.1 | <0.001** |
| Platelet (x10 3 /μL) | 110.8 ± 91.8 | 141.4 ± 94.0 | 99.3 ± 88.4 | <0.001** |
| Serum albumin (g/dL) | 2.7 ± 0.6 | 2.9 ± 0.6 | 2.6 ± 0.6 | <0.001* |
| Serum phosphate (mg/dL) | 5.5 ± 2.8 | 5.0 ± 2.5 | 5.7 ± 2.9 | 0.010** |
| MBP (mmHg) | 73.5 ± 16.3 | 79.0 ± 16.1 | 71.4 ± 15.9 | <0.001* |
| Heart rate (bpm) | 110.8 ± 29.3 | 102.8 ± 27.2 | 113.8 ± 29.5 | <0.001* |
| Mechanical ventilation | 395 (64.5) | 71 (42.5) | 324 (72.8) | <0.001+ |
| Vasopressor use | 445 (72.7) | 85 (50.9) | 360 (80.9) | <0.001+ |
Continuous data are presented as mean ± SD, and categorial data as number of patients (%). BUN, blood urea nitrogen; Hb, hemoglobin; WBC, white blood cell; CRP, C-reactive protein; INR, international normalized ratio; MBP, mean blood pressure.
*p-value by Student’s t-test
**p-value by Mann-Whitney test