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. 2023 May 25;13(5):e1276. doi: 10.1002/ctm2.1276

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Altered circulating intermediary metabolites in patients with alcohol‐associated hepatitis. (A) Plasma tricarboxylic acid (TCA) cycle intermediates lactate, pyruvate, citrate, alpha‐keto glutarate, succinate, fumarate, and malate (HC = 27, HD = 8, AH = 59). (B) TCA cycle intermediates lactate, pyruvate, citrate, alpha‐keto glutarate (αKG), succinate, fumarate, and malate in peripheral blood mononuclear cells (PBMC). *p < .05; ***p < .001. All data expressed as mean ± SD (HC = 18; HD = 8; AH = 69). AH Alcohol‐associated hepatitis; HC healthy control; HD heavy drinkers with no liver disease.