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. 2023 May 25;13(5):e1276. doi: 10.1002/ctm2.1276

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© 2023 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Peripheral blood mononuclear cell senescence in alcohol‐associated hepatitis. Feature extraction of mitochondrial genes was followed by Uniform Manifold Approximation and Projection (UMAP) and Seurat analysis to identify clustering by specific cell type based on mitochondrial gene expression in peripheral blood mononuclear cells (PBMC) from control (HC) or alcohol‐associated hepatitis (AH) subjects at baseline (n = 4 each). Schematic dot‐plot representation of single‐cell RNA sequencing (scRNAseq) data of comparative average expression for (A) Telomere Length; (B) Shelterin complex; (C) Shelterin‐binding genes; (D) Telomerase localisation and (E) DNA damage repair. (F) Experimental validation of telomere length in PBMC by real‐time PCR in HC (n = 13), AH (n = 72) and heavy drinkers (HD) (n = 8). (G) Hazard ratio of mortality based on telomere length in AH (n = 72).