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. 2023 Mar 6;51(2):557–569. doi: 10.1042/BST20221242

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© 2023 The Author(s)

This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). Open access for this article was enabled through a transformative open access agreement between Portland Press and the University of California. Open access for this article was enabled through a transformative open access agreement between Portland Press and the University of California.

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Figure 2. — Current challenges in live-cell SMT, with a focus on transcription regulation, and selected recent advances in overcoming each problem. POI, protein of interest. GOI, gene of interest. PAPA, proximity-assisted photoactivation.