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. 2023 Apr 26;51(2):871–886. doi: 10.1042/BST20220494

Figure 2. Positions of the FG Nups in the yeast NPC.

Figure 2.

Upper: Representation of observed electron density of the central transporter within the rigid frame of the NPC. Upper Right: detailed observed density local to the central waist illustrating the FG repeat anchor site. Center: distribution of types of FG repeats within the central transporter based on their mapped anchor sites and inferred by assuming random coil behavior of the FG segments and the absence of NTR/cargoes [15]. Lower: heat map of the contribution of the FG repeat region of each FG Nup to maintaining the passive permeability barrier limiting the passage of nonspecific macromolecules, which appears to be largely maintained by FG Nups enriched in GLFG repeats forming a cap at the cytoplasmic entrance of the NPC [15]. The severity of the permeability defect measured as permeability relative to permeability in wild type, is indicated in increasing shades from minor (light green) to severe (dark blue). Adapted from [18]. The figure is modified form one copyrighted by MPR.