Skip to main content
. 2023 Feb 14;56(5):e13422. doi: 10.1111/cpr.13422

FIGURE 1.

FIGURE 1

The 5C medium induces higher transdifferentiation in the cortex. (A) Experimental design for implantation of osmotic minipumps into the brain, EdU was delivered simultaneously with 5C medium. (B) Immunofluorescence around the injury sites at 4 weeks after 5C infusion in the cortex and striatum. (C) Quantification of total EdU+ cells in the peri‐injury core areas of the control (F12) and 5C group at 4 weeks after 5C infusion in the cortex and striatum. (D–F) Immunofluorescence for NeuN+GFAP+EdU+ cells in the cortex and striatum at 4 weeks (D). The amounts of these cells (E) and their percentage in EdU+ cells (F) were determined. (G–L) Analyses for NeuN+EdU+ cells (G–I) and GFAP+EdU+ cells (J–L) were performed similarly as in (D–F). Each group included at least six mice and at least seven frozen sections from each mouse were analyzed (n ≥ 42). Error bars represented standard errors. Two‐way ANOVA was used. Additional statistic information could be found in Table S2.