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. 2023 May 17;56(5):e13467. doi: 10.1111/cpr.13467

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© 2023 The Authors. Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Maturation of gene‐modified proliferating human hepatocytes (ProliHHs) after repopulation in vivo. (A and B) The maturation of repopulated ProliHHs was analysed by co‐immunofluorescent staining for F8, Fah, HNF4a and CK19. (C) The liver zonation was analysed by co‐immunofluorescent staining for Fah, CYP3A4, and GS. Arrows depict human hepatocytes positive for hepatic markers GS and Fah. (D) The Comparison of gene expression of mature hepatic markers, such as phase I, phase II enzymes, and transporters genes in PHHs, EV‐ProliHHs, repopulated EV‐ProliHHs in mice liver, and F8‐ProliHHs, repopulated F8‐ProliHHs in mice liver. RNA was extracted from repopulated livers. Human‐specific primers were used in qPCR.