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. 2023 Apr 20;4(5):734–753. doi: 10.1038/s43018-023-00544-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Myeloma cell drug responses (PCY scores) bi-clustered across the cohort of 101 patient samples (columns) and 61 unique drugs and drug combinations (rows). Additional sample and drug annotations are provided at the top and right of the drug response matrix (see legend). For visualization purposes, 21% (1,292 of 6,161) of shown drug responses have been imputed by LASSO regression on either measured drug responses or matching myeloma proteotype data. Imputed drug responses are indicated by a dashed outline. LC, light chain, AVEL, avelumab; BEN, bendamustine; BOR, bortezomib; CAR, carfilzomib; CIS, cisplatin; CYC, cyclophosphamide; CYT, cytarabine; DARA, daratumumab; DEX, dexamethasone; ELOTUZ, elotuzumab; ETO, etoposide; IPILIM, ipilimumab; IXA, ixazomib; LEN, lenalidomide; MEL, melphalan; NIVOL, nivolumab; OBINUTUZ, obinutuzumab; PAN, panobinostat; PEMBROLIZ, pembrolizumab; POM, pomalidomide; PRE, prednisone; THA, thalidomide; VINC, vincristine; VINO, vinorelbin.

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