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. 2023 May 1;4(5):608–628. doi: 10.1038/s43018-023-00548-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — The contribution of immune cells was calculated based on sampling scores of immune cell markers in tumors annotated as a, excluded (n = 26 macro-regions) and infiltrated (n = 15 macro-regions), b, non-smokers (n = 22 macro-regions) and smokers (n = 19 macro-regions), and c, immune high (n = 24 macro-regions) and low (n = 17 macro-regions), per cell type. P values were calculated with a one-sided wilcoxon test. Boxplots show the median (line), the interquartile range (IQR) between the 25^th and 75^th percentile (box) and 1.5*IQR +/− the upper and lower quartile respectively.