Fig. 1 Kaplan–Meier estimates for time to first OSA event on treatment for patients without OSA at baseline. OSA events are based on adverse events that occurred between the date of the first dose of study medication until treatment end plus an additional 14 days. HR, 95% CI, and P value are based on a stratified Cox proportional hazards model that includes categorical terms for treatment, sex, geographical region, baseline BMI, baseline HbA1c, and baseline eGFR, a continuous term for age, and a stratification factor for enrollment cohort. BMI body mass index; CI confidence interval; eGFR estimated glomerular filtration rate; HbA1c glycated hemoglobin; HR hazard ratio; OSA obstructive sleep apnea