Table 4.
Subgroup analysis according to treatment on consecutive days vs. every other day in the full analysis set
| Toxicity | Consecutive, n (%) | Every other day, n (%) | Odds ratio [95% Wald CI] | p-value | |
|---|---|---|---|---|---|
| Cumulative GI toxicity | Yes | 15 (45.45) | 8 (16.00) |
0.23 [0.08; 0.63] |
0.0054 |
| No | 18 (54.55) | 42 (84.00) | |||
| Cumulative GU toxicity | Yes | 27 (81.82) | 40 (80.00) |
0.89 [0.29; 2.73] |
1 |
| No | 6 (18.18) | 10 (20.00) | |||
| Incontinence | Yes | 2 (6.06) | 3 (6.00) |
0.99 [0.16; 6.27] |
1 |
| No | 31 (93.94) | 47 (94.00) | |||
| Nycturia | Yes | 1 (3.03) | 10 (20.00) |
8.00 [0.97; 65.82] |
0.0434 |
| No | 32 (96.97) | 40 (80.00) | |||
| Proctitis | Yes | 21 (63.64) | 8 (16.00) |
0.11 [0.04; 0.31] |
0.00001 |
| No | 12 (36.36) | 42 (84.00) | |||
| Erectile dysfunction | Yes | 5 (15.15) | 3 (6.00) |
0.36 [0.08; 1.61] |
0.2553 |
| No | 28 (84.85) | 47 (94.00) | |||
| Irritative complaints | Yes | 27 (81.82) | 38 (76.00) |
0.70 [0.23; 2.11] |
0.5957 |
| No | 6 (18.18) | 12 (24.00) | |||
| Obstructive complaints | Yes | 4 (12.12) | 11 (22.00) |
2.04 [0.59; 7.07] |
0.3830 |
| No | 29 (87.88) | 39 (78.00) | |||
| Bladder (RTOG) | Yes | 7 (21.21) | 0 (0.00) |
0.04 [0.002; 0.64] |
0.0010 |
| No | 26 (78.79) | 50 (100.00) |
GI gastrointestinal, GU genitourinary, RTOG Radiation Therapy Oncology Group, CI confidence interval