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. 2023 May 25;13:8436. doi: 10.1038/s41598-023-35547-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro transduction assays of AAV WT vs NEM-modified capsids. gLUC signal was measured at 24 h-post transduction. (A) Human fibroblasts GM16095 cells. (B) Human cervical cancer HeLa cells. (C, D) Human umbilical vein endothelium HUVEC cells. (D) Dose-dependent increase in gLUC observed in HUVECs transduced with AAV9-NEM. N = 3/group.