Fig. 1.

3HB Treatment Reduces Insulin Resistance in T2D Mice. a Body weights of db/db mice (n = 10). b Overnight fasted blood glucose level of db/db mice (n = 10). c The glucose tolerance test of db/db mice. Glucose (2 g/kg body weight) was intraperitoneally (i.p.) administered in overnight-fasted db/db mice. (n = 5) d The area under the curve (AUC) in c. e Fasting serum insulin levels of db/db mice after 8 weeks of indicated treatment. (n = 6) f A homeostasis model for assessment of the insulin resistance index (HOMA-IR) of the mice in e. g Body weights of STZ induced T2D mice. (n = 10) h Overnight fasted blood glucose level of STZ mice. (n = 10) i The glucose tolerance test of STZ mice. Glucose (2 g/kg body weight) was intraperitoneally (i.p.) administered in overnight-fasted STZ mice. (n = 5–9) j The area under the curve (AUC) in i. k Fasting serum insulin levels of STZ mice after 8 weeks of indicated treatment. (n = 5–9). l A homeostasis model for assessment of the insulin resistance index (HOMA-IR) of STZ mice. (n = 5–9) Data reported as mean ± SD, *p < 0.05, **p < 0.001, and ***p < 0.0001