REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
AQP8 antibody	Bioss	Cat#bs-6786R, RRID:AB_2934320
SULT1A1 antibody	Bioss	Cat# bs-6283R, RRID:AB_11094764
SLC26A2 antibody	Proteintech	Cat# 27759-1-AP, RRID:AB_2880963
PADI2 antibody	Bioss	Cat# bs-11662R, RRID:AB_2934324
HSD17B2 antibody	Bioss	Cat# bs-3856R, RRID:AB_10858090
FAM162A antibody	Abcam	Cat# ab122295, RRID:AB_11129715
ACADS antibody	Abcam	Cat# ab110318, RRID:AB_10860028
SELENBP1 antibody	Bioss	Cat# bs-4200R, RRID:AB_11086827
TNNC2 antibody	Proteintech	Cat# 15875-1-AP, RRID:AB_2878194
GAPDH antibody	Abmart	Cat# P30008M
Anti-rabbit IgG, HRP-linked antibody	Cell Signaling Technology	Cat# 7074, RRID:AB_2099233
Anti-mouse IgG, HRP-linked antibody	Cell Signaling Technology	Cat# 7076, RRID:AB_330924
Deposited data
Gene expression levels of IBD (inflamed VS. remission) RNA-seq data	N. Planell et al., 20134	GSE38713
Gene expression levels of IBD (inflamed VS. remission) RNA-seq data	M. Boyd et al., 201855	GSE95437
Gene expression levels of IBD (inflamed VS. uninflamed) RNA-seq data	M. E. Keir et al., 202134	GSE179285
Gene expression levels of IBD (inflamed VS remission) RNA-seq data	M. Vancamelbeke et al., 201715	GSE75214
Gene expression levels of IBD (inflamed VS remission) RNA-seq data	W. Vanhove et al., 201518	GSE59071
Gene expression levels of IBD (inflamed VS uninflamed) RNA-seq data	L. A. Peters et al., 201724	GSE83687
Gene expression levels of IBD (inflamed VS uninflamed) single-cell RNA-seq data	K. Parikh et al., 201943	GSE116222
Gene expression levels of IBD restoration after treatment with Olamkicept RNA-seq data	S. Schreiber et al., 202141	GSE171770
Patients’ proteomics datasets	A. Schniers et al., 201932	https://clinicalproteomicsjournal.biomedcentral.com/articles/10.1186/s12014-019-9224-6
Oligonucleotides
q-PCR primers are listed in Table S10	This paper	N/A
Software and algorithms
GraphPad Prism 8.3.0	GraphPad Software	https://www.graphpad.com/scientific-software/prism/
3DHISTECH’s Slide Converter	3DHISTECH Ltd	https://www.3dhistech.com/research/slidecenter/slidemaster/
CaseViewer 2.4	3DHISTECH Ltd	https://www.3dhistech.com/solutions/caseviewer/
R 4.1.0	R Core Team, 202156	https://cran.r-project.org/bin/windows/base/old/4.1.0/
limma 3.48	M. E. Ritchie et al., 20155	https://bioconductor.org/packages/release/bioc/html/limma.html
EdgeR 3.34	Mark D. Robinson et al., 200964	https://bioconductor.org/packages/release/bioc/html/edgeR.html
ClusterProfiler 4.0.0	G. Yu et al., 20123	https://bioconductor.org/packages/release/bioc/html/clusterProfiler.html
CEMiTool 1.16.0	Pedro S. T. Russo et al., 201831	https://www.bioconductor.org/packages/release/bioc/html/CEMiTool.html
Seurat 4.0.5	Yuhan Hao et al., 202158	https://cran.r-project.org/web/packages/Seurat/index.html
Other
Original code	This paper	https://doi.org/10.5281/zenodo.7879748