Figure 1.
Identification and possible function of miR-132 predicted targets in brain
(A) Schematic representation of the identification strategy of predicted miR-132 targets, using an intersection of two target prediction algorithms and a high-confidence threshold for experimental data from AGO-CLIP-seq experiments.62
(B) All significantly enriched GO biological processes and KEGG pathways for 384 predicted miR-132 targets. Color indicates significance (Fisher’s Exact test, p values corrected with false discovery rate (FDR), adjusted p value <0.05 considered significant).
(C) Circos plot depicting cell type-specific expression profiles of predicted miR-132 targets.
(D) Schematic representation of experimental outline. MG, Microglia; OPC, oligodendrocyte precursor cell; NFOL, newly formed oligodendrocyte; OL, oligodendrocyte; AST, astrocyte; RGL, radial-glia like cell; EN, endothelia; NPC, neuronal precursor cell; NB, neuroblast; ExN, excitatory neuron; InN, inhibitory/GABAergic neuron; CR, Cajal-Retzius neuron. See also Table S1.