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. 2023 May 25;14:3012. doi: 10.1038/s41467-023-38303-0

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© The Author(s) 2023

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Fig. 6 — a TM3 and TM10 defined the pocket position of representative states of SLC members’ pockets. b–d Schematic representation showing a complete alternate opening in TMD. e–h Schematic representation showing a hypothetic exchange mechanism. e A thermodynamically stable symmetric inward homodimer in resting state. f binding of anions pair activates the transport of one protomer. Allosterism of two TMDs processes the inverted alternate-access mechanism. pA and pB: protomer A and protomer B, respectively.