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. 2023 Apr 7;16(1):39–62. doi: 10.1016/j.jcmgh.2023.03.009

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© 2023 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Evaluation of autophagy markers in the constitutive Ptpn2-deficient mice. (A) Western blot of ileal IECs probing for autophagy markers LC3B-I and LC3B-II, Beclin-1, autophagy-related proteins ATG3, ATG5 (antibody detects total levels of free ATG5 and conjugated with ATG12), ATG7, ATG12, and ATG16L1. Densitometry of (B) LC3B-I and LC3B-II depicted as a ratio between the 2 isoforms; (C) Beclin-1; (D) ATG3; (E) total ATG5; (F) ATG7; and (G) ATG16L1 protein levels. WT = 8, HET = 8, KO = 8. Columns show means ± SD. One-way analysis of variance and Tukey post hoc test.