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. Author manuscript; available in PMC: 2024 Jun 5.
Published in final edited form as: Angew Chem Int Ed Engl. 2023 Apr 27;62(23):e202216784. doi: 10.1002/anie.202216784

Table 1.

Photophysical and Bactericidal properties of puromycin derivatives 2–4.

Photophysical Properties
 Antibacterial Activity
(MIC)
Cpd. Solvent λabsa λem (ϕ)a Stokes Shifta S. aureus
(29213)b 		B. cereus
(14579)		 S. marcescens
(8100)		 E. coli
(51739)		 E. coli
(25922)
1 PBS 284 n/a n/a 16 8 128 128 64
2 PBS 354 424 (0.004) 4.67 16 8 64 64 32
3 PBS 354 417 (0.21) 4.21 16 8 128 128 64
4 PBS 353 419 (0.31) 4.44 32 16 128 >128 64
a

λabs, λem, and Stokes shift are reported in nm, nm and 103 cm−1 respectively. Photophysical values reflect the average over three independent measurements.

b

MIC values are reported in γg/ml. ATCC designations for the respective bacterial strains are provided in parentheses.