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. 2023 May 12;17:1158408. doi: 10.3389/fnins.2023.1158408

Figure 2.

Figure 2

Stimulating AdMSCs with inflammatory cytokines and prion-infected brain homogenate for 24 h increases production of anti-inflammatory molecules and growth factors. AdMSCs were incubated for 24-h in media containing TNFα or IFNγ. These AdMSCs showed significant increase in mRNA expression levels for (A) TSG-6, (B) TGFβ-1, and (C) VEGF, but no changes in (D) FGF. AdMSCs were incubated for 24-h in media containing NBH or RML-infected brain homogenates. In AdMSCs exposed to RML, a significant increase was seen in (E) TSG-6, (F) TGFβ-1, (G) VEGF, and (H) FGF mRNA. One-way ANOVA with post-hoc Tukey’s test, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, error bars = SEM. Combined data from four separate experiments, each with three technical replicates.