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. 2023 May 12;17:1158408. doi: 10.3389/fnins.2023.1158408

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Copyright © 2023 Hay, Latham, Mumford, Hines, Risen, Gordon, Siebenaler, Gilberto, Zabel and Moreno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adipose-derived mesenchymal stromal cells (AdMSC) treatment decreases inflammatory cytokine transcripts in the hippocampus at 16 weeks post infection (wpi). Hippocampal mRNA expression was decreased in animals treated with AdMSCs for (A) IL1β, (B) CCL5, (C) TNFα, (D) C3, (E) C1qa, (F) NLRP3, (G) Caspase-1, (H) IL18, (I) CD16, and (J) CD32. Hippocampi were analyzed from 10 animals, 6 AdMSC-treated and 4 PBS-treated controls. T-test with Welch’s corrections, *p < 0.05, **p < 0.01, error bars = SEM.