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. 2023 May 12;17:1158408. doi: 10.3389/fnins.2023.1158408

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Copyright © 2023 Hay, Latham, Mumford, Hines, Risen, Gordon, Siebenaler, Gilberto, Zabel and Moreno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adipose-derived mesenchymal stromal cells treatment does not induce detectable changes in PrP^Sc. Western blots were used to compare both PrP^Sc (PK-resistant PrP) and total PrP (not PK-treated) between vehicle and AdMSC-treated mice at (A) 16 wpi, (B) 18 wpi, and (C) terminal stages of disease with no detectable differences between treatments (see Supplementary Figure S7 for quantification). GAPDH is used as loading control. Brain homogenates were analyzed from 10 animals per timepoint, 6 AdMSC-treated and 4 PBS-treated controls (for terminal mice, 7 AdMSC-treated and 3 PBS-treated controls).