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. 2023 May 12;17:1158408. doi: 10.3389/fnins.2023.1158408

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Copyright © 2023 Hay, Latham, Mumford, Hines, Risen, Gordon, Siebenaler, Gilberto, Zabel and Moreno.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Death of hippocampal neurons is not prevented by AdMSC treatment. Swollen and pyknotic neurons in the CA1 region of the hippocampus were compared. (A) Significantly more pyknotic neurons were seen in terminally-infected mice when compared to age-matched NBH mice. (B) No changes were seen between AdMSC-treated and control mice at 16 wpi, 18 wpi or terminal stages of infection. Hippocampi were analyzed from 10 animals per timepoint, 6 AdMSC-treated and 4 PBS-treated controls. T-test with Welch’s corrections, ****p < 0.0001, error bars = SEM. IHC: 20x, IF: 40x representative images, scale bar = 20 μm.