Figure 6.

Norbergenin (Nbn) reverses LPS-induced disordered ECAR and OCR in iBMDMs. (A), Representative ECAR in iBMDMs pretreated with or without Nbn (5 and 50 μM) followed by stimulation with LPS (200 ng/mL) for 8 h. Quantitative results of glycolysis (B) and glycolytic capacity (C). (D), Representative image of OCR in iBMDMs incubated with or without Nbn at concentrations of 5 and 50 μM for 1 h prior to stimulation with LPS (200 ng/mL) for another 8 h. Quantitative results of maximal respiration (E) and spare respiratory capacity (F). Data are presented as mean ± SEM of n = 4 independent experiments. *p < 0.05, **p < 0.01 (unpaired two-tailed student’s t test).