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. 2023 May 12;14:1117638. doi: 10.3389/fimmu.2023.1117638

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Copyright © 2023 Li, Cai, Schindler, Bahiraii, Brenner, Heiss and Weckwerth

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation illustrating the mechanism of norbergenin (Nbn) preventing inflammation in macrophages. Key metabolite and inflammatory pathways that were significantly regulated by LPS or LPS + Nbn are shown. Blue arrow indicates the metabolite expression of LPS vs Control (Ctrl). Red arrow indicates the metabolite expression of LPS + Nbn vs LPS. The arrow direction indicates the increase (↑) or decrease (↓) of the corresponding metabolite caused by LPS vs Ctrl or LPS + Nbn vs LPS.